Zakaria al-Agha was born in 1942 in Khan Younis (Gaza). He was a member of the PLO’s Executive Committee (EC) between 1996-2018, and a member of Fatah's Central Committee (CC) between 1992-2016. Al-Agha currently heads the PLO's Department for Refugee Affairs and was recently assigned by Mahmoud Abbas to help resolve internal disputes and tensions within Fatah in Gaza.
Al-Agha was a member of the Palestinian negotiating team between 1991-1993, as well as a minister of housing in the first Palestinian Authority government between 1994-1995. A medical practitioner by training, he has contributed to various health organisations, such as the Arab Medical Organization, the Palestine Red Crescent Society, and the Blood Bank Organisation.